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Gclm KO mice also exhibit constitutive activation of liver AMP-activated protein kinase (AMPK) pathway and nuclear factor-erythroid 2related factor 2 target genes, and show enhanced ethanol clearance, altered hepatic lipid profiles in favor of increased levels of polyunsaturated fatty acids and concordant changes in expression of genes associated with lipogenesis and fatty acid oxidation
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It is most commonly supplied as the iodide salt, with the molecular formula C10H11IN2, a molecular weight of approximately 286.11 g/mol, and CAS number 42464-96-0
