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The activity of a human endoplasmic reticulum-associated degradation E3, gp78, requires its Cue domain, RING finger, and an E2-binding site
IGF-1 elevation led to the accumulation of FOXO3A in the cytosol of prostate tumor cells and downregulation of its target gene Bim , which resulted in the apoptosis inhibition and prostate cancer overgrowth
Always consult with your healthcare provider to determine whether these therapies are right for you
Wang J-M, Chao J-R, Chen W, Kuo M-L, Yen JJY, Yang-Yen H-F
