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This differential tissue regulation of these enzymes results in increased BCAAs in adipose tissue, a decrease in liver BCAAs and no change in skeletal muscle

the combination is a likely mechanism of enhanced ischemic injury in the aging heart [37]

Acetyl L-Carnitine is produced within the kidneys and liver and is transported and used by other tissues in the body

Overall, this work broadens the understanding of nuclear-cytosolic acetyl-CoA metabolism and opens new avenues for investigation into the regulation of de novo lipogenesis and histone acetylation
