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The PROGNOSIS study [25] clearly demonstrated that sFlt-1/PlGF ratio of 38 or lower can be used to rule out the onset of preeclampsia within one week with a negative predictive value higher than 99%

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Though moderate gastrointestinal side effects, e.g., nausea or diarrhea, may occur at greater doses, myo-inositol generally has a favorable safety profile, with daily intakes up to 12 g being regarded as well-tolerated [42]