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Biochemical assessments measured oxidative stress markers [superoxide dismutase (SOD), catalase, and glutathione (GSH)], proinflammatory cytokines (TNF, IL-6, and IL-1), and brain monoamines [dopamine (DA) and acetylcholine (ACh)]

Although paracetamol is safely broken down into harmless byproducts when taken in normal doses, excess use or prolonged usage can produce toxic metabolites like N-acetyl-p-benzoquinone imine (NAPQI) that can cause liver damage and even be fatal

have an unhealthy diet, smoke or drink alcohol

Attach for more than 4 hours to allow the active ingredients to be well absorbed into the skin