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Within this context Opuwari et al

FIGURE 4 The previously documented constituents demonstrate multi-target efficacy against VEGF-driven tumor angiogenesis: fucoidan exhibits pan-inhibitory efficacy across diverse malignancies, including multiple myeloma (RPMI-8226, U266) and breast cancer (4T1), which suppresses VEGF expression to potently ameliorate tumor neoangiogenesis (Xue et al., 2012

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By modulating astrocytic activity through targeted regulation of relevant signaling pathways, it may be possible to improve cognitive function and safeguard against neurodegenerative diseases (Verkhratsky and Nedergaard, 2018)