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A combination of assays, including CSF -syn and other biochemical indicators, MRI imaging markers, SPECT or PET imaging, non-motor symptoms, and cognitive function scores, should be utilized to detect early PD because individual biomarkers are difficult to diagnose reliably

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While it is recommended to get up to 16 milligrams of niacin, it may be safe for most people to take niacinamide supplements in doses less than 35 milligrams per day

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