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When you have an injury, inflammation, or gut damage, your cells are working overtime to repair the damage

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They have a condition that makes them need extra folate Examples include certain types of anemia, pregnancy and skin diseases

[1] Because the cypionate ester markedly increases lipophilicity, the subcutaneous or intramuscular depot undergoes gradual enzymatic hydrolysis, releasing free estradiol that is chemically identical to endogenous estrogen and capable of binding to nuclear estrogen receptors in target tissues
