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Moreover, Ascorbic A

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Additionally, GW2580, a selective CSF1R inhibitor, has been shown to normalize tumor vasculature and reduce malignant ascites in experimental ovarian cancer models by limiting M2 macrophage-mediated vascular permeability

Studies have found that HFD can stimulate pro-inflammatory signaling cascades, increase cytokines (TNF-, IL-1, IL-6, and IFN-) that disrupt the barrier, and decrease cytokines (IL-10, IL-17, and IL-22) that promote barrier formation, thereby enhancing intestinal permeability