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Similarly, metabolomics has emerged as a novel tool facilitating comprehensive component analysis, proving valuable for identifying changes in metabolites induced by various environmental fluctuations (Zhang et al., 2021)

Discussion To the best of our knowledge, this is the first study to demonstrate that dual-mode laser therapytargeting both pigment and vascular components of melasmais safe and more effective across multiple clinical parameters compared with single-mode treatment targeting only pigmentation

Oral glutathione supplements are the most common and convenient form, though bioavailability can vary depending on the specific formulation

Moreover, it has been proposed that de novo cysteine synthesis via transsulfuration pathway can be fundamental to tumor growth in vivo when extracellular apport of cysteine is limited, demonstrating that the methylation status of the cell (SAMe/SAH ratio) can assist cancer progression under these conditions [57]