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Although preclinical studies suggest antitumor activity via modulation of the cell cycle, apoptosis, and angiogenesis, large-scale randomized controlled trials have not demonstrated a clear benefit in terms of cancer incidence or mortality (11)

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Additionally, chronic stress activates the hypothalamic-pituitary-adrenal axis, resulting in excessive glucocorticoid release and the regulation of mtDNA transcription and mtRNA expression (45)