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Many patients find relief through dose reduction, slower escalation, or temporary pause

Analysis of pathway mutations, copy-number changes, and other genetic alterations in 9,125 tumors profiled by The Cancer Genome Atlas in 33 cancer types showed that these alterations are frequent in carcinomas of the pancreas, gastrointestinal tract, lungs, breast, bladder, prostate, endometrium, and head and neck, as well as in low-grade gliomas and diffuse large B-cell lymphomas