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Mifflin L et al

82 TomiokaK.KurumataniN.HosoiH

In the attempts to study CAD and the causative agents for the disease, a metabolite circulating in the plasma termed trimethylamine-N-oxide (TMAO) has been found out to be an independent risk factor that increases CAD risk

The mouse model exhibited a phenotype with a large increase in levels of the enzyme substrate trimethyllysine (TML) and very low carnitine levels
