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Influences HPA axis regulation and cortisol dynamics: The hypothalamic-pituitary-adrenal (HPA) axis governs physiological stress responses through sequential CRH, ACTH, and cortisol release

Research Applications and Experimental Context In laboratory settings, these peptides are studied across a range of experimental models that explore: inflammation-related signaling pathways tissue organization and adaptation immune system communication cellular response to environmental stress Their relevance lies in how they contribute to understanding complex biological systems, rather than isolated mechanisms

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doi: 10.1136/jitc-2022-005660 177 LowryBSJonusHCLeeJSpencerTHKenneyAMGoldsmithK