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Nat Biotech 29:625634 Wold S, Sjstrm M, Eriksson L (2001) PLS-regression: a basic tool of chemometrics

You must be well informed, medically literate to a reasonable degree, clear eyed about your goals, and cognizant of the true nature of risk

Probably due to the binding preference of APAP to the active site of each P450 isomer, it is oxidized via two pathways to form the toxic intermediate N-acetyl-p-benzoquinone imine (NAPQI) and the non-toxic catechol metabolite 3-hydroxy-APAP (3-OH-APAP) (Chen et al., 1998)

Genetics, age, injury severity, overall health, concurrent treatments all influence outcomes