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Nat Biotech 29:625634 Wold S, Sjstrm M, Eriksson L (2001) PLS-regression: a basic tool of chemometrics

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You must be well informed, medically literate to a reasonable degree, clear eyed about your goals, and cognizant of the true nature of risk

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Probably due to the binding preference of APAP to the active site of each P450 isomer, it is oxidized via two pathways to form the toxic intermediate N-acetyl-p-benzoquinone imine (NAPQI) and the non-toxic catechol metabolite 3-hydroxy-APAP (3-OH-APAP) (Chen et al., 1998)

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Genetics, age, injury severity, overall health, concurrent treatments all influence outcomes

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