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Through upregulation of their activity, E3 modulates the production of reactive oxygen species (ROS), which are key mediators of oxidative stress

Differential Diagnosis The differential diagnosis for PCT includes other forms of the porphyrias (including variegate porphyria, congenital erythropoietic porphyria, hepatoerythropoietic porphyria, and hereditary coproporphyria), pseudoporphyria, other bullous skin disorders (including bullous pemphigoid, bullous drug eruption, epidermolysis bullosa, epidermolysis bullosa acquisita, and bullous lupus erythematosus), and hydroa vacciniforme, a rare chronic photodermatosis

(Cham: Springer International Publishing), 113126

Dental caries