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We demonstrated that APOE4 suppressed the ARMs, also known as DAMs, and promoted a G2 lipid-laden senescent-like state

E., Gallegos-Infante, J.-A., Atienzo-Lazos, M., Drzewiecki, J., Martnez-Snchez, C

To test this hypothesis experimentally, we created two truncated APOE M variants: (i) aggregation-prone APOE M -AP with truncated helices N1 and N2 (residues 1-23), and (ii) aggregation-suppressed APOE M -AS with the same truncation, but carrying additional four mutations (R38A, E45A, E49A, and R145A)