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Researchers also utilized the characteristics of tumor-specific initiator factors/trans-acting factors (IF/ITAF) to identify the internal ribosome entry site (IRES) of the virus, encoding the IRES sequence of human rhinovirus type II (HRV2) before the GSDMD mRNA, thereby endowing the LNP drug GSDMDENG circRNA with the ability to target tumors, allowing more LNPs to accumulate in the tumor area and reducing systemic cytotoxicity [31]

Armstrong M

Schizophrenia (Heidelb) 2023;9:69