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Most flavonoids, with the exception of 4,5-dihydroxyanthrquinone-2-carboxylic acid (RHein), are competitive antagonists of CD38, which likely lead to an increase in cellular NAD + levels and activation of NAD-dependent enzymes such as SIRTUINs (8)

This safety profile, demonstrated across multiple clinical trials for metabolic applications, may make it suitable for long-term joint support applications without the risks associated with traditional GH therapy