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They look at the patients needs and health

There's no evidence of tachyphylaxis (desensitization) with AOD-9604 since it doesn't affect the GH axis, but cycling is still recommended due to limited long-term human data

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Similarly, a study based on swimming exercise for a total of four hours showed an increase in NAD + levels, yet also in this case, no measurements of mitochondrial function were performed 309 , reinforcing the need for more exercise-based investigations to further define how NAD + and mitochondrial homeostasis are perturbed and connected during exercise