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Description
doi: 10.3390/ijms252111724

These short-acting satiety and hunger signals are transmitted via afferent fibers of the vagus nerve to the caudal brainstem in nucleus tractus solitarius, from where they also influence the hypothalamus

Since DSIP appears to influence sleep architecture and circadian signaling, injecting 13 hours before your target sleep time tends to produce the best results
However, all safety data comes from a single lab, no long-term studies exist, and the FDA cited specific safety concerns (immunogenicity, aggregation, impurities) in its 2023 ban
