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Moreover, the use of small molecular oral agents to inhibit this pathway as opposed to biologic inhibitors of cytokines, makes this approach even more appealing

In the typical DctBD TCS, extracellular dicarboxylates are expected to bind to the periplasmic input domain of DctB and stimulate the phosphorylation of a conserved histidine residue within its cytoplasmic transmitter domain

J Biol Chem (1999) 274:1390814

[DOI] [PubMed] [Google Scholar] 122.Chen M, Cai H, Yu C, Wu P, Fu Y, Xu X, Fan R, Xu C, Chen Y, Wang L, Huang X
