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Since serine feeds into one-carbon metabolism supporting nucleotide synthesis, methylation reactions, and redox homeostasis, blocking serine synthesis can have pleiotropic anti-tumor effects

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Glutathione peroxidase moves the cycle forward

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Their therapeutic effects primarily involve strengthening antioxidant defenses by enhancing GPX4 and GSH activity, reducing ROS accumulation, and limiting iron-induced lipid damage, thereby protecting hepatocytes

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10.1183/09031936.94.07030431 81 MouthuyP

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