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(2) Microenvironment-informed targeting: The melanoma lymph node work suggests that in vitro drug response may underestimate efficacy because FSP1 dependence can be imposed by in vivo constraints 117

[DOI] [PMC free article] [PubMed] [Google Scholar] 15.Vignais PV

However, the efficacy of glutamine inhibitors in selectively targeting certain tumors while concurrently impeding the immune response of the host organism is a salient concern

Mitchell, KG, Parra ER, Nelson DB, Corsini E, Zhang J, Vaporciyan AA, Hofstetter WL, Mehran RJ, Swisher SG, Rice DC , Sepesi B, Walsh GL, Behrens MC, Kalhor N, Weissferdt A, Moran C, Skoulidis F, Wistuba II, Fujimoto J, Roth, JA, Antonoff MB