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2.2.2 The impact of ROS on mitochondria Mitochondrial dysfunction is a critical pathological component in the mechanism of cellular damage associated with insulin resistance

A prominent study that made an explicit effort to account for adaptation and income growth (Carleton et al., 2022) calculated a ~10% increase in total death rates under a future scenario of high emissions (RCP8.5) and low GDP growth (SSP3), but there was great spatial heterogeneity in the projection with net death rates increasing in the tropics, and net death rates decreasing at higher latitudes (Fig

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