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B12 injections offer a range of benefits beyond addressing vitamin B12 deficiency, including reducing the risk of associated complications, aiding in weight loss, and addressing hair loss concerns

296,298 One case report described the benefit of SAMe in a 32 year old patient with anxiety who was found to have a MTHFR gene mutation: treatment with methylated B 12 and folate was not effective for relieving symptoms until SAMe, 400 mg twice daily, was added

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Injections are given subcutaneously (just under the skin), and injection sites should be rotated daily to prevent lipoatrophy or irritation