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10.1038/s41419-021-03563-5 129 GonzalezB

16S rDNA sequence analysis The microbial sequencing analysis was performed by Allwegene Tech

Other irAE research has focused on the role of human leucocyte antigen (HLA) genes, a complex of genes involved in regulating immune responses, that may be implicated in the development of particular autoimmune diseases, such as atopic dermatitis and IBD

At this level, pharmacological approaches targeting folate metabolism, such as developing folate analogs with improved bioavailability and agents modulating MTHFR activity, may offer innovative therapeutic strategies in neurodegeneration