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Implications of OCTN2 in Cancer To date, several studies reported a link between the altered expression of OCTN2 and cancer development and progression (Scalise et al., 2012

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Studies in mice revealed that dietary supplementation with TMAO, choline, or carnitine decreased reverse cholesterol transport (RCT) (Janeiro et al., 2018), a mechanism that counteracts excess cholesterol deposition in peripheral tissues by transporting excess cholesterol to the liver and small intestine (Ross and Glomset, 1973).The major pathway for cholesterol elimination is the metabolic synthesis of bile acids in the liver (Zarate et al., 2016), and it was reported that the size of the total bile acid pool was significantly smaller in mice administered TMAO (Koeth et al., 2013)

Treatment Options for Carnitine Deficiency When someone has primary carnitine deficiency, they usually need to take high doses of oral L-carnitine (100 to 200 mg/kg) for the rest of their life