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Key Challenges Identified -Equinus deformity secondary to a previous tendo-Achilles injury persistent forefoot overload -Osteomyelitis of the metatarsal heads ongoing deep-seated infection -Large chronic ulcer with surrounding scar tissue due to multiple previous surgeries poor local biology and compliance issues -Simply dressing the wound was never going to be enough

Moreover, GHK-Cu promotes bone healing and enhances osteoblastic cell attachment, potentially through the increase in collagen synthesis [14-15]

Thus, fibrosis can be decreased by preventing NLRP3 activation in these cells [171, 172]

Glycosidases are often overexpressed in certain pathological conditions, such as cancer or lysosomal storage diseases, making glycosidase-cleavable linkers an effective tool for achieving site-specific drug activation