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In the mid-1980s, kynureninase (Stevens, 1985) and GTK (identical to kynurenine aminotransferase isozyme I, KAT I) (Stevens et al., 1986) were identified as major cysteine S -conjugate -lyases of rat liver and kidney cytosol, respectively (DCVC as substrate)

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While compounds such as bitopertin, BI 425809, and SSR103800 have demonstrated potential in early-stage clinical and preclinical studies, translating these findings into viable treatments remains complex, necessitating further in-depth investigations (Javitt 2012)