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Activating HER2 mutations as emerging targets in multiple solid cancers

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Heparin nanocarrier loaded with cisplatin and Olaparib downregulates MRP-2 and P-gp resulting in intracellular accumulation of cisplatin and Olaparib causing downregulation of PI3K/AKT/mTOR signaling pathway which enhances the anti-proliferation of cisplatin against CR OC [61]
