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Thus, CB1 activation has mixed aversive and rewarding effects that could affect the abuse potential in different individuals

Laboratory investigations show that BPC-157 administration significantly enhances ERK1/2 phosphorylation in a dose-dependent manner, leading to increased endothelial cell proliferation, migration, and vascular tube formationthe central processes underlying functional angiogenesis in tissue regeneration contexts

Response varies with the severity and chronicity of the injury

Hydration and texture often improve in 1-2 weeks, firmness and fine lines around 6-12 weeks, and the biggest changes build over 3-6 months of consistent use