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The theoretical 3-8% additional weight loss from adding cagrilintide to tirzepatide doesn't justify the significantly amplified side effects, 2-3x higher cost ($1,200-2,400 monthly), lack of physician support for experimental protocols, and unknown long-term safety profile

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The potential change appears to have put doctors largely at odds with the pharmacy compounding industry: at least one poll suggests 90% of physicians are worried about patients self-directed peptide use, while compounding pharmacies argue the change would give Americans a safer supply of drugs than what they are already using

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The settlement related to NIH grant applications that relied on the compromised Benoist data

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