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These observations, in turn, reflect the fact that defective sperm function is frequently associated with the retention of excess residual cytoplasm as a result of impaired cytoplasmic extrusion during spermiogenesis

The Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA) criteria ( in vivo , in vitro , and clinical studies

The trials assessed different cognitive outcomes

Enzyme stability: Stable in plasma (not degraded by plasma enzymes)
