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doi: 10.1073/pnas.042707999 77 MatthiasLJYamPTJiangXMVandegraaffNLiPPoumbouriosPet al
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This creates a positive feedback loop where COX-2 activity is further boosted increasing the production of pro-inflammatory prostaglandins, which exacerbate oxidative stress and tissue damage (Simmons et al., 2004
