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10.1016/s0092-8674(02)00722-5 Cell 123 PandaS.HogeneschJ

They are working in direct opposition

Often called a "facelift in a bottle" by marketers, to me, they are simply one of the most powerful biological signals we have available for skin health and longevity

These can include transient redness, mild swelling, or a fleeting sensation of discomfort