melanotic macule lip treatment Mystery behind labial and oral macules: Clinical, dermoscopic and pathological aspects of Laugier-Hunziker syndrome melanotic macule lip treatment oral

SCAD was initially thought to produce severe problems including progressive muscle weakness, hypotonia, acidemia, developmental delay, and even early death

(PubMed) Zhang Y, Chen J, Qiu J, Li Y, Wang J, Jiao J

These include a number of organic acidemias, defects of fatty acid oxidation and of the carnitine cycle (such as very long chain acyl-CoA dehydrogenase (VLCAD), medium chain acyl-CoA dehydrogenase (MCAD), long-chain 3-hydroxyacyl-CoA dehydrogenase (LCHAD), carnitine palmitoyltransferase 2 (CPT-2), and carnitine-acylcarnitine translocase (CACT) deficiencies)

doi: 10.1002/cbin.10955 159 NguyenKTSethAKHongSJGeringerMRXiePLeungKPet al