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Although metabolic cell death inducers such as copper ionophores (e.g., Elesclomol) and disulfiram have been studied in other cancers and non-cancer (e.g., NCT06635252, NCT05210374), confirming certain translational potential, no active clinical trials currently focus on melanoma patients

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This activation disrupts the equilibrium between pro-inflammatory and anti-inflammatory processes, particularly within brain tissues (Proneth and Conrad, 2019)

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