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Remarkably, among the different treatments, only hPBGD mRNA administration restored TG levels to control values (figure 6E,F), in accordance with its unique ability to downregulate diacylglycerol O-acyltransferase 1 ( DGAT1 ) and carnitine palmitoyltransferase 1 ( CPT1 ) gene expressions, which are essential genes in TG synthesis and the mitochondrial oxidation of long-chain fatty acids, respectively (online supplemental figure 7B)

L-carnitine supplementation improves athletic performance with significant changes in free fatty acids, triacylglycerols, lactic acid [44], ability in high-intensity exercise with an increase of VO 2 and a decrease of plasma lactate and pyruvate [26,29], increasing performance during endurance training by attenuating the increase in blood lactate and oxidative stress [1,25,28,29,38]

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Journal of Gastroenterology and Hepatolology 35(9): 16281635