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RNA sequencing analysis revealed that palbociclib treatment induces features previously reported in senescence cells 40 , with top upregulated Enricher terms being senescence and autophagy, cytokines and inflammatory response, PI3K-AKT-mTOR survival pathway and TGF-beta regulation of extracellular matrix (Fig

Takeshita T, Morio M, Kawahara M, Fujii K