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Gut bacteria produce metabolites that can bind to DNA and influence the expression of genes regulating nutrient intake and metabolism

One well studied case is that of busulfan (as shown in Scheme 8) [126], an anti-cancer drug now widely employed to suppress lymphocytes and blood cell stem precursors prior to performing life-saving bone marrow transplantation in malignant diseases and in inborn blood diseases [127,128]

Common dosing: 0.11 mg/kg total peptide via subcutaneous injection, split into 10100 g/kg per component

Oral glutamine in the prevention of fluorouracil induced intestinal toxicity: A double blind, placebo controlled, randomised trial