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The tested animals that were listed in the patent include rats, mice, rabbits, guinea pigs and pigs, as well as a single study in humans

Given that implanted chondrocytes are responsible for the generation of new cartilage in the defect site, it is not surprising that the quality of these cells critically affects the reparative results of ACI treatment (Davies and Kuiper, 2019)

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pH 7.2 adjusted with HCl and NaOH with 0.1 dilution of trace element solution (41 mM CaCl 2 , 22 mM FeSO 4 , 6 mM MnCl 2 , 3 mM CoCl 2 , 1 mM ZnSO 4 , 0.1 mM CuCl 2 , 0.2 mM (NH 4 ) 6 Mo 7 O 24 , 17 mM EDTA) with kanamycin (25 mg l-1) in which 15 N-NH 4 Cl (2 g l-1) was the only source of nitrogen for NMR isotope labelling purposes, respectively (Cambridge Isotope Laboratories, Inc)