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[21] reported an alertness-increasing effect of VitB12 supplementation, with a decrease in sleep duration

More help Handbook Version v1.0 Graphical Representation A graphical representation of the AOP.This graphic should list all KEs in sequence, including the MIE (if known) and AO, and the pair-wise relationships (links or KERs) between those KEs

To assess whether our in vitro system can monitor dose-dependent toxicity, we analyzed in a cohort of 50 individuals the effect of acetaminophen (APAP), a prototypical intrinsic DILI drug that causes predictable and dose-related toxicity in nearly all individuals at high concentrations(Figure 5A)