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[DOI] [PMC free article] [PubMed] [Google Scholar] Bell E.F
The development of predictive biomarkers to identify patient subgroups that would benefit most from these therapies represents a crucial unmet need

In fact, because the RFC pathway is less efficient, studies use high doses of leucovorin to ensure enough folate reaches the brain

Huebner F, Lieberman K, Rubino R, Wall J
