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The most frequent symptoms are: Developmental delays Anaemia Loss of appetite Chronic vomiting Weight loss Low brain volume Spasms/cramps Apathy Irritability In the most severe instance, vitamin B12 deficiency can lead to respiratory failures and coma (51)

Despite this, it was debated whether GPCRs in particular act solely as monomeric structures or if they oligomerize to form complexes with different characteristics from its constituent parts

Arthur JM, Forrest JC, Boehme KW, Kennedy JL, Owens S, Herzog C, et al

Proteomic analysis of the acid-soluble organic matrix of the chicken calcified eggshell layer
