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The use of Optifolin+ rather than standard folic acid is clinically significant: up to 40% of people have MTHFR polymorphisms that impair folic acid conversion, and folic acid supplementation may be largely ineffective for COMT-dependent methylation in this population.*

J Pakistan Assoc Dermatologists

[DOI] [PMC free article] [PubMed] [Google Scholar] 623.Mahesh M., Pandey H., Raja Gopal Reddy M., Prabhakaran Sobhana P., Korrapati D., Uday Kumar P., Vajreswari A., Jeyakumar S.M
