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These biological insights have fueled the era of precision oncology, where tumor-specific molecular aberrations can be paired with targeted drugs designed specifically for that alteration

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When FSH binds to its receptor in the granulosa cells, the intracellular portion of the receptor develops a higher affinity for G proteins and APPL1, a leucine-zipper-containing protein that activates phosphatidyl-inositol-3-kinase (PI3K) and Akt, leading to transcriptional regulation and PIP3 production (Figure 3A)

Nano Lett 23:476490 [DOI] [PubMed] [Google Scholar] 54.Wang Y, Jiang J, Fu X, Zhang J, Song J, Wang Y, Duan L, Shao P, Xu X, Zeng L et al (2022) Fe3O4@polydopamine nanoparticle-loaded human umbilical cord mesenchymal stem cells improve the cognitive function in Alzheimers disease mice by promoting hippocampal neurogenesis