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Additional risk factors include: Chronic kidney disease : Reduced renal clearance may impair B12 excretion Liver disease : Hepatic dysfunction can disrupt B12 metabolism and storage Myeloproliferative disorders : Certain blood cancers increase B12-binding proteins Concurrent medication use : Some drugs may interact with B12 metabolism, including metformin, proton pump inhibitors, and H2 antagonists Patients with these conditions should have B12 supplementation carefully monitored by their healthcare team

(1996) [Effect of vitamin B12 on sleep quality and performance of shift workers]

JBSNF-000088 has emerged in research settings for its potential involvement in metabolic regulation and obesity-associated pathways

The Science Behind It: Metformin interferes with Vitamin B12 absorption in the ileum by disrupting a calcium-dependent transport mechanism
