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Pseudo-HS refers to pigmentation visible through the translucent cuticle or proximal nail fold [Figure 2b], while micro-HS denotes subtle periungual pigmentation detectable only on close inspection or onychoscopy

Finally, remodeling occurs simultaneously with tissue formation through processes involving cell maturation, cell apoptosis, ECM contraction resulting from the transition of fibroblasts to myofibroblasts, and the conversion of type III collagen to type I collagen through the coordinated actions of matrix metalloproteinases (MMPs) and tissue inhibitors of metalloproteinases (TIMPs)

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