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This ratio of GSH:GSSG is maintained by the action of the enzyme GSSG reductase (also known as glutathione reductase) which requires NADPH+ as the reducing cofactor

Clinicians utilizing these findings have developed targeted treatment protocols, often referred to as the "Brewer Protocol," which focus on eradicating fungal colonization in the sinus cavities using biofilm disruptors and intranasal antifungals

37,38 Biofilms both physically prevent drugs from reaching all cells and induce stress responses, such as the production of enzymes that neutralize drugs

Chronic stress may contribute to the development of functional GI disorders and exacerbate existing conditions, emphasizing the importance of stress management in overall gastrointestinal health